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Nasihun, Taufiqurrachman
- Administration of Purwoceng (Pimpinella alpina Molk) Improves Oxidative Stress Biomarker Following UVC Irradiation in Spargue-Dawley Male Rats
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Authors
Affiliations
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Central Java, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, Central Java, ID
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Central Java, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, Central Java, ID
Source
Journal of Natural Remedies, Vol 16, No 3 (2016), Pagination: 115-124Abstract
Introduction: UVC may induce oxidative stress mediated by ROS. Pimpinella alpina Molk (PaM) have been utilized by aging male as rejuvenation remedy. Objective: To elucidate the PaM effect on oxidative stress biomarker in rats. Methods: 25 of Sprague-Dawley male rats were divided into 5 groups, PaM with a dosage of 50, 100, and 150 mg were administered during 15 days to evaluate the biomarker of oxidative stress following UVC irradiation for 30 minutes beforehand. The oxidative stress biomarkers were measured by TBARS and FRAP assay respectively. Results: Post Hoc analysis demonstrated that MDA and 8-OHdG concentration in PaM group were significantly lower (p < 0.001), otherwise the concentration of TAC in PaM group were significantly higher, p < 0.001. Conclusion: Administration of PaM with 50, 100, and 150 mg dosage capable of improving oxidative stress biomarker in Sprague-Dawley male rats.Keywords
MDA, 8-OHdG, Oxidative Stress Biomarker, Pimpinella alpine Molk, UVC.References
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- Treatment of Thyponium Flageliforme in Combination with Curcuma Zedoaria, and Phyllanthus Niruri Synergistically Enhances Apoptotic and Anti-Proliferative Effect on Breast Cancer
Abstract Views :321 |
PDF Views:174
Authors
Affiliations
1 Department of Anatomy and Master Program of Biomedical Sciences of Sultan Agung Islamic University, Semarang, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, ID
3 Department of Biochemistry, and Master Program of Biomedical Sciences of Sultan Agung Islamic University, Semarang, ID
1 Department of Anatomy and Master Program of Biomedical Sciences of Sultan Agung Islamic University, Semarang, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, ID
3 Department of Biochemistry, and Master Program of Biomedical Sciences of Sultan Agung Islamic University, Semarang, ID
Source
Journal of Natural Remedies, Vol 17, No 1 (2017), Pagination: 1-8Abstract
Introduction: Breast cancer is the most common cancer and the second leading cause of cancer death in women. Combinations of Thyponium flageliforme, Curcuma zedoaria and Phyllanthus niruri (TCP) have been proven as immunomodulator and retarded tumor progression in vivo. Objective: to investigate the apoptotic and anti-proliferative effect of TCP in C3H mice suffered from adenocarcinoma cells. Methods: 18 mice inoculated with one million cells of breast adenocarcinoma per mouse were assigned into three groups, TCP with dosage 85 and 125 mg were treated for 21 days to evaluate tumor volume, expression of Ki-67 and Capase3. Expression of Ki-67 and Capase3 were measured by immunohistochemistry staining, whilst cancer volume was assessed using calipers. Results: Mann Whitney analysis indicated that tumor volume in TCP groups were lower, otherwise for expression of caspase3, p < 0.05 respectively. Whereas expression of Ki-67 in TCP groups was lower, but not significant, p > 0.05. Conclusion: TCP treatment with 85 and 125 mg dosage capable of reducing tumor volume, increasing caspase3 and lowering Ki-67 expression.Keywords
Apoptosis, Breast Cancer, Thyponium flageliforme, Tumor Volume.References
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- Porang Glucomannan Supplementation Improves Lipid Profile in Metabolic Syndrome Induced Rats
Abstract Views :274 |
PDF Views:161
Authors
Affiliations
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, ID
2 Department of Biochemistry and Master Program of Biomedical Sciences, Sultan Agung Islamic University, Semarang, ID
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, ID
2 Department of Biochemistry and Master Program of Biomedical Sciences, Sultan Agung Islamic University, Semarang, ID
Source
Journal of Natural Remedies, Vol 17, No 4 (2017), Pagination: 131-143Abstract
Background: Porang glucomanan has been shown to have a potential properties for the prevention of Metabolic Syndrome (MetS). This study aimed to confirm that porang glucomannan supplementation can improve lipid profile in metabolic syndrome induced rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into 5 groups consisting a contol group standard diet (Normal); Metabolic Syndrome group (SM), metabolic syndrome group+25 mg/200 gBW Porang Glucomannan (GMP25), metabolic syndrome group+50 mg/200 gBW Porang Glucomannan (GMP50), and metabolic syndrome group+100 mg/200 gBW Porang Glucomannan (GMP100). The lipid profile before and after induction with high-fat and high-carbohydrate diet, and after 28 days of porang treatment were evaluated. Data were analyzed using One Way Anova followed by LSD post hoc test. Results: GMP100 rats showed the highest reversal of diet-induced changes, with decreased total cholesterol (TC), triglycerides (TG), and LDL, and also increased HDL level. The mean levels of TC, TG, and LDL in GMP100, GMP50 and GMP25 was significantly lower than those of in MS (p=0.000), and was significantly higher than those of normal (p=0.000). While the levels of HDL in GMP 100, GMP50, and GMP25 was significantly higher than those of MS (p=0.000), but significantly lower than those of normal (p = 0.000). Conclusion: Porang glucomannan supplementation improve lipid profile in metabolic syndrome diet rats, with best dose at 100 mg/200 gBW.Keywords
Glucomannan, Lipid Profile, Metabolic Syndrome, Porang.References
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- Effect of Thyponium flageliforme in Combination with Curcuma zedoaria and Phyllanthus niruri in Expression of Protein Estrogen Receptor and Caspase-9 on Breast Cancer Mice
Abstract Views :304 |
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Authors
Affiliations
1 Department of Chemistry, Sultan Agung Islamic University, Jawa Tengah - 50112, ID
2 Department of Anatomy, Sultan Agung Islamic University, Jawa Tengah - 50112, ID
3 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Jawa Tengah - 50112, ID
1 Department of Chemistry, Sultan Agung Islamic University, Jawa Tengah - 50112, ID
2 Department of Anatomy, Sultan Agung Islamic University, Jawa Tengah - 50112, ID
3 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Jawa Tengah - 50112, ID
Source
Journal of Natural Remedies, Vol 18, No 1 (2018), Pagination: 21-28Abstract
Introduction: Incidence of breast cancer is high and constitutes a significant cause of female mortality. One of breast cancer type is Estrogen and Progesteron Receptor (ER and PR) positive, therefore affected by estrogen and progesteron concentration. Treatment of Thyponium flageliforme in combination with Curcuma zedoaria, and Phyllanthus niruri (TCP) have been proven capable of inhibiting tumor cells proliferation. Objective: To evaluate the expression of protein estrogen receptor and caspase-9 in C3H mice were inoculated with adenocarcinoma cells. Methods: 18 mice were inoculated with one million cells of breast adenocarcinoma per mouse and assigned into three groups. TCP with dosage 85 and 125 mg were treated for 21 days to evaluate the expression of protein estrogen receptor and caspase-9 measured by immuno-histochemical staining. Results: Mann Whitney analysis demonstrated that expression of protein estrogen receptor and caspase-9 in TCP 125 was significant (p < 0.05). Conclusion: Expression of protein estrogen receptor was decreased and caspase-9 expression was increased by TCP administration.Keywords
Breast Cancer, Caspase9, Combination of Herbal Extracts, Estrogen Receptors.References
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- Rahman A S M, Wahab AN, Malek ASN. In vitro morphological assessment of apoptosis induced by anti proliferative constituents from the rhizomes of Curcuma zedoaria. Evidence-Based Complementary and Alternative Medicine. 2013; 257108:1–14. Crossref. PMid:23762112 PMCid:PMC3671673
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- Widayati E, Nasihun T. Treatment of Pimpinella Alpina Molk improve oxidative stress and inhibit liver cellular apoptosis in rats following UVB irradiation: Is there any correlation? Bangladesh Journal of Medical Science. 2018; 17(1):118–28. Crossref.
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- Lakshmi S, Padmaja G, Remani P. Antitumoureffects of isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cells. International Journal of Medicinal Chemistry. 201; 253962:1–13.
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- Pimpinella alpina Molk Administration is Capable of Increasing Antioxidant and Decreasing Prooxidant Level Following UVB Irradiation
Abstract Views :381 |
PDF Views:149
Authors
Affiliations
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, ID
1 Department of Biochemistry, Sultan Agung Islamic University, Semarang, ID
2 Department of Chemistry, Sultan Agung Islamic University, Semarang, ID
Source
Journal of Natural Remedies, Vol 18, No 1 (2018), Pagination: 29-39Abstract
Introduction: Indonesian male population has traditionally used Pimpinella alpina Molk (PaM) to prevent degenerative disease. However, the scientific evidence of PaM effect on increase in antioxidant and decrease in prooxidant level and their negative correlation remains unclear. Objective: To prove the effect of PaM on increase in antioxidant and decrease in prooxidant and their negative correlation following Ultraviolet B (UVB) exposed repeatedly. Methods: Forty male rats were assigned into 8 groups, treatment groups for 7 days: PaM 50 mg (PaM50-7), PaM 100 mg (PaM100-7), PaM 150 mg (PaM150-7), and for 15 days: PaM 100 mg (PaM100-15), PaM 150 mg (PaM150-15). The increase in antoxidant and decrease in prooxidant levels were measured by ELISA and Spectophotometer. Results: Statistical analysis indicated that antioxidant Catalase (CAT) and Super Oxyde Dismutase (SOD) activities in PaM groups were significantly higher, p < 0.001. In contrary, prooxidant levels marked by Malondialdehide (MDA) and 8-hydroxy-2-deoxyguanosine (8OHdG) concentrations in PaM groups were significantly lower, p < 0.001. There was also a negative correlation between antioxidant and prooxidant levels, p < 0.001. Conclusion: PaM administration with 50-150 mg daily dosage for 7-15 days capable of increasing antioxidant and decreasing Prooxidant levels, with a negative correlation following UVB irradiation repeatedly.Keywords
Oxidative Stress, Pimpinella alpina Molk, CAT, MDA, SOD, 8OHdG.References
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- Effect of Zamzam Water Extract of Curcuma zedoaria Treatment on Apoptosis, P53 and Bcl2 Protein Expression of T47D Cell Culture
Abstract Views :305 |
PDF Views:152
Authors
Affiliations
1 Department of Chemistry, Sultan Agung Islamic University, Central Java Tengah – 50112, ID
2 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Central Java – 50112, ID
3 Department of Anatomy, Sultan Agung Islamic University, Central Java – 50112, ID
1 Department of Chemistry, Sultan Agung Islamic University, Central Java Tengah – 50112, ID
2 Department of Biochemistry, Sultan Agung Islamic University, Semarang, Central Java – 50112, ID
3 Department of Anatomy, Sultan Agung Islamic University, Central Java – 50112, ID
Source
Journal of Natural Remedies, Vol 18, No 3 (2018), Pagination: 100-106Abstract
Introduction: People worldwide drink Zamzam water either medicinally or religiously. However, the effect of zamzam water extract of CZ in breast cancer cells remains unclear. Objective: To evaluate the zamzam water extract of CZ effect on cell apoptosis, p53 and Bcl2 protein expression in T47 D cells line culture. Methods: In the control group design, 16 Wells which was filled with T47 D cell line culture in the density of 5 × 104/100 μl, were assigned into 4 groups. Control group (C-G), were only filled with T47D cell line culture; Zamzam 50 (ZZ-50); Zamzam 100 (ZZ-100), and Zamzam 500 (ZZ-500) groups, were filled with T47D cell line cultures and 50, 100, and 500 μg/ml zamzam water extract of CZ respectively, and then incubated for 48 hours. The number of apoptotic cell was counted by flow cytometry, while p53 and Bcl2 measured by immunohistochemistry staining method. Results: Mann Whitney analysis indicated that the percentage of apoptotic cell and p53 protein expression in ZZ-100 was significant higher compared to that of C-G (p < 0.05). In contrary the percentage number of Bcl2 protein expression in ZZ100-G was significantly lower when compared to that of C-G (p < 0.05). Conclusion: Treatment of zamzam water extract of CZ on T47D cell line cultured was capable of increasing the number of apoptotic cells, p53 protein expression, but decreased Bcl2 protein expression in T47D cell line culture. However the numbers of apoptotic cells were less than 10%.Keywords
Apoptosis, Breast Cancer, Chemoprevention, Flavonoids, P53 Mutan.References
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